b'Scientific Session Abstracts SATURDAY APRIL 20, 2024 8: BENEFICIAL UTILITY OF AN ON-SITE TISSUE BANK CRYOPRESERVED HUMAN VASCULAR ALLOGRAFT CRYOFREEZER AT AN ACADEMIC MEDICAL CENTERNishant Sharma, MD, Mennatalla Hegazi, MD, Nii-Kabu Kabutey, MD;Samuel L Chen, MD, Isabella J Kuo, MD, Anthony H Chau, MD,Roy M Fujitani, MDUniversity of California Irvine Medical Center; Department of Surgery,Division of Vascular and Endovascular Surgery; Orange, CAObjectives: Cryopreserved human vascular allografts (CHVA) may serve as alternative conduits when autogenous or in-situ/extra-anatomic prosthetic grafts are not readily available. Unscheduled urgent or emergent surgeries add challenges to immediate access to alternative allografts. This study reviewed the experience of on-site tissue bank freezer used to store CHVA (Artivion, Inc. Kennesaw, Ga) at an academic medical center to facilitate urgent or emergent vascular surgical treatments.Methods: Single-center, retrospective review conducted on patients using CHVA during Jan 2016 - Dec 2022 for urgent/emergent surgery. Demographics, index procedural detail, perioperative & postoperative complications & CHVA patency analyzed. CHVA-related mortality & failure by reinfection, hemorrhage, aneurysmal degeneration, & thrombosis analyzed as primary endpoints.Results: 68 pts (27 female & 41 male, mean age 62.9 yrs) had 73 CHVA vascular reconstructions using 2 aortoiliac arteries; 55 femoropopliteal arteries; 11 great saphenous veins; & 15 femoral veins. 48/73 (66%) were performed as unplanned, urgent/emergent surgeries in infected or contaminated fields. Surgical repairs included aortoiliac (n=7), iliofemoral (n=21), femoropopliteal-tibial (n=24), axillosubclavian or brachial (n=10), mesenteric (n=11) configurations. Ten surgeries used more than one CHVA. Mean follow-up was 8.93 mos. (range 0.07-43.3 mo.). 30-day mortality was 2.9%. ABO matching was not routinely performed. CHVA related complication including major amputations (n=3) and graft stenosis (n=6) & aneurysmal degeneration (n=1). There were no CHVA reinfections.Conclusions: Immediate availability of CHVA with an on-site freezer bank at an academic medical center provided significant benefit in providing access to allograft conduits for unplanned, urgent/emergent surgical situations when autogenous or in-situ/extra-anatomic reconstructions in infected or contaminated fields are not readily available. CHVA provides immediate vascular reconstructions with acceptable resistance to graft failure, reinfection, and may provide acceptable interval patency for subsequent definitive repair.42 NDANNUAL MEETING|APRIL 1921, 2024|OCEANSIDE, CA 47'